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Clinical Research Center

Hawaii Pacific Neuroscience Clinical Research Center (CRC) proven model, and combined years of experience affords us the ability to provide Hawaii patients with groundbreaking new neuroscience treatment options.

Center Overview

The Hawaii Pacific Neuroscience Clinical Research Center (CRC) is a proven model with decades of combined years of experience that affords us the ability to provide our local patients with ground-breaking neuroscience treatment options.

Our staff includes 8 full-time Investigators, 5 dedicated full-time research staff and over 10 administrative support staff with Regulatory, Quality Assurance, Business Development, Recruitment Specialists roles included. Our CRC has an active database of over 20,000 subjects and growing. Principal Investigator, Kore Liow, MD, is an NIH trained research neurologist who has served as the PI for over 20 years for more than 100 phase I through IV neuroscience clinical trials funded by NIH, CDC, and the industry. He also has published over 40 peer-reviewed scientific neuroscience articles.

According to NIH NIMHD (National Institute on Minority Health & Health Disparities), one of America’s greatest challenges is reducing the profound disparity in health status of its racial and ethnic minority, rural, low-income, and other underserved populations. Hawaii is one of the most diverse state and home to several NIMHD designated US health disparity populations including:

Asian Americans (40% of Hawaii’s Population)

Native Hawaiians and other Pacific Islanders including Socioeconomically disadvantaged populations in Underserved Rural areas (94% of Total Land area housing 8% of population in Hawaii)

The Hawaii Pacific Neuroscience CRC’s goal is to contribute to NIH NIMHD’s goals of “enhancing the scientific knowledge base and designing interventions to improve health outcomes to reduce and ultimately lead to the elimination of health disparities’ by ensuring that clinical trials include racial and ethnic diversity including minority groups that constitute substantial and growing proportions of the US population. For example, according to the 2010 US census, 6% of those identified themselves as Asian. It is important for clinical trial populations to reflect the targeted patient population. Our Clinical Research Center strives to represent the trial populations that are an important facet of clinical trial designs and positively contribute to the scientifically rigorous evaluation of therapies being investigated to ensure that the safety and efficacy profile of a treatment is accurate.

Hawaii Pacific Neuroscience is committed to improving health care access, reducing health disparities especially for minorities and those underserved in our state and are proud to be working with organizations to serve these populations. Further information, contact Principal Investigator Kore Kai Liow, MD, kliow@HawaiiNeuroscience.com

Clinical Research

Principal Investigator

Dr. Kore Kai Liow is a board-certified neurologist with over 20 years of clinical research experience. He has personally served as the PI for over 100 Phase I-IV neuroscience clinical trials. His research has been published in over 40 peer-reviewed publications and has received the “Honolulu Top Doctors” award in 2015, 2016 and 2017.

Regulatory & Start Up Department

Our CRC Regulatory Specialists process the start-up paperwork with a turn-around time of less than one week and work diligently to maintain all regulatory documents throughout the study.

Clinical Research Department

Our CRC Coordinators and Assistants are the backbone of the department. They work directly under the PI and manage the day-to-day logistics of the clinical trials. The team leaders have extensive research experience and provide oversight with the PI to ensure the proper management of multiple trials.

Pharmacy Department

Our CRC licensed pharmacy technician provides oversight and direction of the pharmacy department to keep track of all IP involved including receiving, inventory, tracking, dispense, drug distribution and providing technical assistance with clinical protocol including coordinating, collaborating and providing expertise in support of the clinical trials as well improving patient experience in education of AEs.

Recruitment & Business Development

Our CRC Recruitment and Business Development Team work closely with the PI and Study Coordinators to pursue all avenues of patient recruitment, which leads to our study site frequently exceeding the enrollment standards set by our study sponsors.

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EDC Capabilities

Recent Achievements (2017-2018)

  • #1 Recruitment site for Western US in ALZHEIMER’S DAYBREAK Eli Lily study
  • #1 Recruitment site in US for EPILEPSY Aquestive Monosol PK study
  • #1 Recruitment site in US for PARKINSON’S Tozadenant Biotie study
  • FIRST in US to fulfill enrollment quota in OMB MS (MULTIPLE SCLEROSIS) Novartis study
  • FIRST in US to screen and enroll patients in EPILEPSY Padsevonil ARISE UCB study
  • FIRST in US to screen and enroll patients in EPILEPSY Natalizumab Biogen Study

Recent Products Investigated at Clinical Research Center, Approved by FDA and Launched in US.

  • Inbrija for Parkinson’s (Successfully Tested at CRC 2016-2018)
  • XCorpi for Epilepsy ( Successfully Tested at CRC 2016-2019)
  • Kesimpta for MS ( Successfully Tested at CRC 2018-2021)
  • Valtoco for Epilepsy ( Successfully Tested at CRC 2017-2019)

Alzheimer's Research Unit

Parkinson's Research Unit

MS & Neuroimmunology Research Unit

Sleep & insomnia Research Unit

Headache & Migraine Research Unit

Neuromodulation Research Unit

Epilepsy Research Unit

Vaccine Research Unit

Stroke Research Unit

Pain Research Unit

ALS Research Unit

Brain Health & Wellness


  • 20 exam rooms
  • Dedicated research/monitor rooms
  • 24 hour/day staffed phase 0 overnight PK unit
  • 24 hour/day staffed phase I overnight PK unit
  • Onsite IV Infusion with dedicated research IV staff
  • AASM (American Academy of Sleep Medicine) Accredited 4-bed overnight Sleep Laboratory
  • Onsite ABRET accredited EEG labs and  Video-EEG Epilepsy Monitoring Unit (EMU)
  • Onsite AASM accredited Sleep lab
  • Onsite EMG
  • On-site ECG machine(s)
  • On-site 3T MRI Machine/Radiology Department
  • Onsite Spinal Tap/LP Fluoroscopic Facility with onsite Neuroradiologist
  • Onsite Pharmacy
  • Onsite approved rates for Cognitive and Neurologic ratings (UPDRS) 
  • Onsite Emergency resuscitation equipment
  • Accredited Local Laboratory
  • Experience with the use of Central laboratories
  • Staff is IATA certified
  • Blood Pressure devices
  • Refrigerator
  • -20C freezer
  • -70 Freezer
  • Ambient temperature centrifuge
  • Refrigerated centrifuge
  • High-Speed Internet included in the monitor rooms
  • Study-dedicated fax machine
  • Locked/secure Drug storage that is temperature controlled and monitored daily
  • Facility for long-term storage of files for completed studies
  • Ongoing GCP training

For more

contact the research hotline at (808) 564-6141 or email: Info@HawaiiNeuroscience.com

Meet Our

Multidisciplinary Team

Dr. Kore Kai Liow MD, FACP, FAAN


Principal Investigator, Clinical Research Center,
BRITL (Brain Research, Innovation & Translation Labs)
BCI (Brain Computer Interface) & Brain Mapping Lab
Director, Center for Neurostimulation,
Comprehensive Epilepsy Center, Memory Disorders Center

Dr. Jason Chang MD

Physical Medicine & Rehabilitation

Chief Strategic Officer
Director, Spine & Pain Management
Neuromuscular Rehabilitation Center
Subinvestigator, Clinical Research Center

Dr.Jason Viereck MD, PhD


Director, Parkinson's & Movement Disorders Ctr
Comprehensive MS Center, Stroke & Neurologic Rehabilitation Center

Dr. Sriharsha Vajjala MD

Internal Medicine/Sleep Medicine

Subinvestigator, Clinical Research Center

Dr. Vimala Vajjala MD


Director, Video-EEG Epilepsy Monitoring Unit
Neurodiagnostic Institute of Technology,
Headache & Facial Pain Center

Dr. Paul Smith MD

Lifestyle Medicine

Director, Self Care & Wellness Center

Dr. Qing X. Li PhD

Basic Science

Dr. Kent Yamamoto MD

Physical Medicine & Rehabilitation
Director, Concussion & TBI Center

Dr. Todd Uchima MD


Clinical Research Center

Dr. Chris Larrinaga, APRN-BC, MSN, CNRN


Clinical Research Center

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